Abbott Laboratories 15-minute COVID-19 test…a Game Changer

Abbott Labs receives FDA emergency use authorization for their 15-minute, $5 COVID-19 test

The FDA has granted emergency use authorization to Abbott Laboratories for the company’s BinaxNOW, a 15-minute COVID-19 test that will be priced at $5.

Abbott says BinaxNOW works without relying on lab equipment – at a time when labs can take as long as two weeks to produce results – and uses a nasal swab and a small reactive card that can be administered by a range of healthcare workers, including pharmacists.

BinaxNOW is an antigen test, the size of a credit card, with no equipment required and results delivered in 15 minutes, using proven lateral flow technology. It lets trained healthcare providers test a lot of people for active infections, a lot faster, on a single-use test.

Rapid antigen tests perform well while eliminating the waiting game. While lab tests have the highest sensitivity, you have the trade-off of not knowing results for several days and the risk of infecting others. Rapid tests deliver actionable results quickly so that infected patients can immediately begin self-quarantine. This test, along with others like it, is risk reduction on a community scale.

BinaxNOW is also transformative in Abbott Lab’s ability to produce it in large volumes, which is what the country needs more than anything today.

The company plans to ship “tens of millions’ of test in September, ramping to 50M tests per month by the end of October. The new test “can be used at a massive scale to help overcome the current waiting game for test results,” according to John Hackett, divisional VP of applied research and technology at Abbott Diagnostics.

Abbott Labs is pairing BinaxNOW rapid test with a mobile app, called NAVICA, which works like a secure digital “boarding pass” that can be scanned to enter organizations and other places where people gather. This combination of rapid test and mobile app stands as game-changing technology.


References:

  1. https://www.cnbc.com/2020/08/27/abbott-labs-ceo-testing-covid-19-at-massive-scale-is-best-strategy.
  2. https://www.abbott.com/BinaxNOW-Test-NAVICA-App.html

Doc Rivers

Doc Rivers, Head Coach, NBA Los Angeles Clippers, expressing frustration and anger regarding the shooting in the back of Jacob Blake by a police officer in Kenosha, Wisconsin.

Additionally, Kenosha police officers, sworn to “serve and protect”, take no action to stop a white militia group member vigilante with a long gun who kills two protesters and wounds a third.

Small Businesses Are Dying by the Thousand | Bloomberg

“Small Businesses Are Dying by the Thousands — And No One Is Tracking the Carnage”

By Madeleine Ngo, August 11, 2020, 9:08 AM EDT

  • They simply close down and never show up in bankruptcy tallies
  • More than half of owners are worried their firm won’t survive

The COVID-19 pandemic has impacted virtually all businesses in one way or another. But the divide between small businesses and large organizations has never been clearer. “Big companies are going bankrupt at a record pace, but that’s only part of the carnage.  By some accounts, small businesses are disappearing by the thousands amid the COVID-19 pandemic, and the drag on the economy from these failures could be huge.”

Massive corporations have the cash and/or borrowing power to stay afloat for many months, the majority of small businesses do not. And we’re beginning to feel the effects.  Economists project that more than 100,000 American small businesses have already shut down permanently since March. This suggests that at least 2 percent of all small businesses are now gone (never to return). And this is just the very tip of the iceberg.

According to a separate study that was conducted in April, as many as 7.5 million small businesses will be permanently shut down if business disruptions continue unabated. More than 90 percent of them will be companies with fewer than 20 employees.

“This wave of silent failures goes uncounted in part because real-time data on small business is notoriously scarce, and because owners of small firms often have no debt, and thus no need for bankruptcy court.”

“Yelp Inc., the online reviewer, has data showing more than 80,000 small businesses permanently shuttered from March 1 to July 25. About 60,000 were local businesses, or firms with fewer than five locations.”

Small businesses are the backbone of the American economy.

“While the businesses are small individually, the collective impact of their failures could be substantial. Firms with fewer than 500 employees account for about 44% of U.S. economic activity, according to a U.S. Small Business Administration report, and they employ almost half of all American workers.”

“Small business attrition is high even in normal times. Only about half of all establishments survive for at least five years, according to the SBA. But the swiftness of the pandemic and the huge drop in economic activity is hitting hard among typically upbeat entrepreneurs. About 58% of small business owners say they’re worried about permanently closing, according to a July U.S. Chamber of Commerce survey.”

Read more: https://www.bloomberg.com/news/articles/2020-08-11/small-firms-die-quietly-leaving-thousands-of-failures-uncounted?utm_campaign=news&utm_medium=bd&utm_source=applenews


References:

  1. https://www.bloomberg.com/news/articles/2020-08-11/small-firms-die-quietly-leaving-thousands-of-failures-uncounted?utm_campaign=news&utm_medium=bd&utm_source=applenews
  2. https://www.washingtonpost.com/business/2020/05/12/small-business-used-define-americas-economy-pandemic-could-end-that-forever/
  3. https://www.cnbc.com/2020/04/14/7point5-million-small-businesses-are-at-risk-of-closing-report-finds.html

U.S. FDA Approves COVID-19 Plasma Treatment for Emergency Use Authorization

Eradicating the coronavirus, whether it’s through an effective therapeutic treatment or vaccine, is the key to unlocking the economy.

The U.S. Food and Drug Administration’s granted emergency use authorization of antibody-rich plasma from recovered patients which may lessen the severity of the disease, but experts suggest further research is needed.

Convalescent plasma therapy is an experimental treatment that some physicians are using for people with severe coronavirus disease 2019 (COVID-19). The plasma therapy has shown some promise in battling severe illness. People who’ve recovered from COVID-19 have antibodies — proteins the body uses to fight off infections — to the disease in their blood. The blood from people who’ve recovered is called convalescent plasma.

Researchers hope that convalescent plasma can be given to people with severe COVID-19 to boost their ability to fight the virus. It also might help keep people who are moderately ill from becoming more ill and experiencing COVID-19 complications, according to the Mayo Clinic.

Alex Azar, the U.S. health and human services secretary, said during a White House press briefing on Sunday that the treatment has been delivered to more than 70,000 American patients so far. The treatment, according to the FDA’s evaluation, “may be effective in lessening the severity or shortening the length of COVID-19 illness in some hospitalized patients.”

Source: The New York Times Coronavirus Vaccine Tracker

Over 400 vaccines and therapietic treatments are under study as researchers rush to produce effective medicines for the disease. And, 32 of the vaccines are in human trials. The FDA says that for any vaccine to be approved, it will need to prevent infection or decrease its severity in at least 50% of the people vaccinated. The goal is to inoculate enough people with a vaccine that immunity spreads through a community, even if not everyone gets the vaccine. It’s called “herd immunity”, according to WebMD.

For this coronavirus, some experts say about 60% to 70% of the population would need to develop antibodies, whether from a vaccine or getting and recovering from COVID-19, to create herd immunity.

Currently, the most effective ways to protect yourself and others from being infected by the virus are to:

  • Clean your hands frequently and thoroughly
  • Avoid touching your eyes, mouth, and nose
  • Cover your cough with the bend of elbow or tissue
  • Stay home and isolate yourself if you feel ill or ‘under-the-weather’
  • Maintain social physical distance of at least 6 feet from others

Wearing a mask or face covering is no substitute for these additional effective measures.


References:

  1. https://www.mayoclinic.org/tests-procedures/convalescent-plasma-therapy/about/pac-20486440
  2. https://www.cnet.com/news/coronavirus-plasma-treatment-approved-for-emergency-use-but-questions-remain/
  3. https://www.webmd.com/lung/news/20200610/covid-19-latest-updates

Federal Debt has Surpassed the Size of the U.S. Economy | New York Times

By Matt Phillips. Aug. 21, 2020 Updated 7:48 a.m. ET

The national debt of the United States now exceeds the size of the nation’s gross domestic product. That was once considered by economists a doomsday scenario that would wreck the U.S. economy. So far, that hasn’t happened.

“Economists and deficit hawks have warned for decades that the United States was borrowing too much money. The federal debt was ballooning so fast, they said, that economic ruin was inevitable: Interest rates would skyrocket, taxes would rise and inflation would probably run wild.”

“The death spiral could be triggered once the debt surpassed the size of the U.S. economy — a turning point that was probably still years in the future.”

“It actually happened much sooner: sometime before the end of June 2020.”

“”This is a 40-year pattern,” said Stephanie Kelton, a professor of economics and public policy at Stony Brook University and a proponent of what’s often called Modern Monetary Theory. That view holds that countries that control their own currencies have far more leeway to run large deficits than traditionally thought. “The whole premise that deficits drive up interest rates, it’s just wrong,” she said.”

“At the end of last year, the United States was about $17 trillion in debt — roughly 80 percent of the gross domestic product. In January, government analysts predicted that debt would approach 100 percent of the G.D.P. around 2030. But by the end of June, the debt stood at $20.63 trillion, or roughly 106 percent of G.D.P., which shrank amid widespread stay-at-home orders. (These numbers don’t count trillions more the government owes itself in bonds held by the Social Security and Medicare trust funds.)”

“Economists have long told a story in which debt levels this large inevitably ignited an economic doom loop. Towering levels of debt would freak out Treasury bond investors, who would demand higher interest rates to hand their cash to such a heavily indebted borrower. With its debt payments more expensive, the government would have to borrow even more to stay current on its obligations.”

“Neither tax increases nor spending cuts would be attractive, because both could slow the economy — and any slowdown would hurt tax revenues, meaning the government would have to keep borrowing more. These scenarios frequently included dire predictions of soaring interest rates for business and consumer borrowing and crushing inflation as the government printed more and more money to pay what it owed.”

“But instead of panicking, the financial markets are viewing this seemingly bottomless need for borrowing benignly. The interest rate on the 10-year Treasury note — also known as its yield — is roughly 0.7 percent, far below where it was a little over a year ago, when it was about 2 percent.”

“There’s a debate about whether a large amount of government debt hamstrings economic growth over the long term. Some influential studies have shown that high levels of debt — in particular debt-to-G.D.P. ratios approaching 100 percent — are associated with lower levels of economic growth. But other researchers have found that the relationship isn’t causal: Slowing economic growth might lead to higher levels of debt, rather than vice versa.”

“Others have found that they don’t see much of a relationship between high levels of debt and slow economic growth for rich developed countries.”

“The experience over the last decade has drastically shifted the way economists and investors think about how the United States funds itself.”

Read more: https://www.nytimes.com/2020/08/21/business/economy/national-debt-coronavirus-stimulus.html?referringSource=articleShare

SalivaDirect – FDA authorizes new saliva based COVID-19 test

Food and Drug Administration (FDA) commissioner Stephen Hahn called the development of a new and inexpensive saliva test for COVID-19 ”ground-breaking.” The new COVID test, which uses saliva instead of nasal swabs, is also a much less intrusive test than the nasal test.

The Food and Drug Administration on Saturday authorized emergency use of a new and inexpensive saliva test for Covid-19 that could greatly expand testing capacity. The new test is called SalivaDirect and was developed by researchers at the Yale School of Public Health.

The test method allows saliva samples to be collected in any sterile container. And, it is a much less invasive process than the nasal swabs currently used to test for the virus that causes Covid-19, but one that has so far yielded highly sensitive and similar results. This test is being further validated as a test for asymptomatic individuals through a program that tests players and staff from the National Basketball Association (NBA).

SalivaDirect is simpler, less expensive, and less invasive than the traditional method for nasal swab testing. Results so far have found that SalivaDirect is highly sensitive and yields similar outcomes as nasal swabbing.

“We simplified the test so that it only costs a couple of dollars for reagents, and we expect that labs will only charge about $10 per sample,” said Nathan Grubaugh, a Yale assistant professor of epidemiology. “If cheap alternatives like SalivaDirect can be implemented across the country, we may finally get a handle on this pandemic, even before a vaccine.”

With the FDA’s emergency use authorization, the testing method is immediately available to other diagnostic laboratories that want to start using the new test, which can be scaled up quickly for use across the nation. A key component of SalivaDirect is that the method has been validated with reagents and instruments from multiple vendors.


References:

  1. https://khn.org/morning-breakout/fda-signs-off-on-fast-inexpensive-saliva-test/
  2. https://news.yale.edu/2020/08/15/yales-rapid-covid-19-saliva-test-receives-fda-emergency-use-authorization

Well-Being and Positive Thinking

“Good thoughts and actions can never produce bad results; bad thoughts and actions can never produce good results…We understand this law in the natural world, and work with it; but few understand it in the mental and moral world – although its operation there is just as simple and undeviating – and they, therefore, do not cooperation with it.” – James Allen

Gallup’s research into wellbeing found that “a life well-lived” requires the fulfillment of several elements: Career, Emotional, Physical, Community and Financial wellbeing.

In this article, we will highlight the impact that positive thinking impact on overall well-being. Essentially, a person’s wellbeing — whether thriving, struggling or suffering — can be affected by one’s thinking.

Positive thinking: Stop negative self-talk to reduce stress

“Positive thinking is more than just a tagline. It changes the way we behave. And I firmly believe that when I am positive, it not only makes me better, but it also makes those around me better.” – Harvey Mackay

Positive thinking helps with stress management and can even improve your health, according to the Mayo Clinic. Positive thinking may reflect your outlook on life, your attitude toward yourself, and whether you’re optimistic or pessimistic — and it may even affect your health.

Studies have shown that optimism can affect your health and well-being. The positive thinking that comes with optimism is a key part of effective stress management. And effective stress management is associated with many health benefits.

Understanding positive thinking and self-talk

“The greatest discovery of all time is that a person can change his future by merely changing his attitude.” – Oprah Winfrey

Positive thinking doesn’t mean that you’re a Pollyanna and ignore life’s less pleasant situations. Positive thinking just means that you approach unpleasantness in a more positive, courageous and productive way. Instead of giving into fear (False Expectations Appearing Real) and worry, you think the best is going to happen, not the worst.

Positive thinking often starts with self-talk. Self-talk is the endless stream of unspoken thoughts that run through your head. These automatic thoughts can be positive or negative. Some of your self-talk comes from logic and reason. Other self-talk may arise from misconceptions that you create because of lack of information, according to the Mayo Clinic.

If the thoughts that run through your head are mostly negative, your outlook on life is more likely pessimistic. If your thoughts are mostly positive, you’re likely an optimist — someone who practices positive thinking.

The health benefits of positive thinking

Researchers continue to explore the effects of positive thinking and optimism on health. Health benefits that positive thinking may provide include:

  • Increased life span
  • Lower rates of depression
  • Lower levels of distress
  • Greater resistance to the common cold
  • Better psychological and physical well-being
  • Better cardiovascular health and reduced risk of death from cardiovascular disease
  • Better coping skills during hardships and times of stress

It’s unclear why people who engage in positive thinking experience these health benefits. One theory is that having a positive outlook enables you to cope better with stressful situations, which reduces the harmful health effects of stress on your body and mental well-being.

It’s also thought that positive and optimistic people tend to live healthier lifestyles — they get more physical activity, have stronger relationships, follow a healthier diet, and don’t smoke or drink alcohol in excess.


  1. https://www.gallup.com/workplace/267152/financial-wellbeing-pays-off.aspx
  2. https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/positive-thinking/art-20043950
  3. https://www.huffpost.com/entry/positive-thinking_b_3512202

FedEx’s Fred Smith Quotes on Leadership

  • What follows are Fred Smith, Founder, Chairman of the Board and CEO of FedEx, quotes on leadership.
    1. “Leadership is simply the ability of an individual to coalesce the efforts of other individuals toward achieving common goals. It boils down to looking after your people and ensuring that, from top to bottom, everyone feels part of the team.”
    2. “Leaders get out in front and stay there by raising the standards by which they judge themselves—and by which they are willing to be judged.”
    3. “The greatest leadership principle I learned in the Marine Corps was the necessity to take care of the troops in a high performance based organization.
      The Marine Corps’ strong emphasis on this overriding leadership requirement has been of inestimable importance to me in developing FedEx over the years.  In the main, people want to be commited to an organization and to do a good job.  The principles of leadership taught by the USMC, and based on two centuries of experience, will produce outstanding organizational results in any setting, if those principles are studiously followed. In short, FedEx owes its success to this simple truth.”
    4. “I’m not afraid to take a swing and miss.”
    5. “The riskiest strategy is to try to avoid risk altogether.”
    6. “Fear of failure must never be a reason not to try something.”
    7. “A manager is not a person who can do the work better than his men; he is a person who can get his men to do the work better than he can.”
    8. “My innovation involved taking an idea from the telecommunications and banking industries, and applying that idea to transportation business.”
    9. “You can’t make people do what’s right. You can lead them, and you can empower them to make the right decision, but if you don’t produce a culture that allows them to do that, then all the rest is just bumping your gums as one of my old business partners used to say.”
    10. “If you’re going to run a high service organization, you have to get the commitment of the people working for that organization right at the start. If you don’t, you’ll never be able to deliver at the levels of expectations of the customer.”

    —Fred W. Smith, Chairman, CEO, Entrepreneur and Founder of FedEx


    All About Fats | VAntage Point

    Fat is one of our macronutrients (along with protein and carbohydrates), and it is an essential part of our intake. It has many functions within the body, including organ protection, providing fuel, coating nerve cells, making up organs (our brains are roughly 60% fat), making up cells (lipid bilayer), nutrient and phytochemical absorption, skin/hair/nail health, and hormone balance.

    As with anything diet related, the first step is to evaluate the source of your food. Are you eating mostly real, whole foods from nature, or processed, refined foods from the grocery store shelf.

    Good sources of fat are going to come from those whole food options.

    Tips

    1. Continue to eat real, whole foods, and follow a system (such as the healthy plate) to guide you to a balanced intake.
    2. Include good fats, such as from olives and olive oil, avocados, nuts and seeds, fatty fish, coconut oil, eggs, dairy, minimally processed meat, and even butter (especially if it’s grass fed and organic). Remember that, although we shouldn’t fear fat from animals, we should still get plenty of it from antioxidant-rich plant-based foods. Balance is important.
    3. Avoid the following: fast food, fried foods, heavily processed meats, processed/packaged foods – like TV dinners and box meals – refined sugars and sweets (including sugar from fluids); highly processed vegetables oils, such as soy, corn, safflower, as well as Crisco and other hydrogenated oils.

    The fat sources we choose, as well as the overall quality of our diet and lifestyle, will make a huge difference on whether that fat will be helpful or harmful.

    Eat well!

    Source: Sieger Giroux MS, RD, LDN is a registered dietitian at the Marion VA. In this episode of Fresh Focus, MOVE! Dietitian Sieger Giroux provides insight on saturated and unsaturated fats and how listeners can incorporate those into the healthy plate method.


    References:

    1. https://www.blogs.va.gov/VAntage/77632/fresh-focus-4-healthy-plate-method-about-fats/