COVID-19 Lung and Heart Damage

Posted on September 12, 2020 by admin

“Your immune system in response to COVID-19 infection can become overzealous and go rogue – attacking and killing healthy cells in the body“.

COVID-19 patients suffer lung and heart damage, but there’s encouraging news for many “long-haulers” — COVID-19 patients who have continued showing symptoms for months after the initial infection — report neurological problems including confusion, difficulty concentrating, heart and lung issues, fatigue, insomnia, plus loss of taste and/or smell.

Cytokines are inflammatory immunologic protein

The immune system is there to help us fight infection, but sometimes it wreaks more havoc than the disease itself.

“There is evidence now that the virus can directly attack heart muscle cells, and there’s also evidence that the cytokine storm that the virus triggers in the body not only damages the lungs, but can damage the heart,” according to John Swartzberg, a clinical professor emeritus of infectious diseases and vaccinology in the the UC Berkeley-UCSF Joint Medical Program.

Inflammatory proteins, also known as cytokines, serve as molecular messengers between cells. Cytokines are proteins that are produced by cells and play a crucial role in the immune response. Cytokines interact with cells of the immune system in order to regulate the body’s response to disease and infection, as well as mediate normal cellular processes in the body.

If this immune response is too strong, a phenomenon known as “cytokine storm” can cause harm to the patient. It has been thought that a cytokine storm contributes to disease severity in patients with COVID-19.

“Cytokine storm”…your body may not know how to handle the presence of the coronavirus and overreact.” Reynold Panettieri, M.D., a lung specialist and vice chancellor for translational medicine and science at Rutgers University

With viral infections like COVID-19, our immune system can become overzealous and go rogue – attacking and killing everything in sight, including healthy cells in the body. When “cytokine storm” happens, it may kill severe COVID-19 patients.

“Cytokines are inflammatory immunologic proteins that are there to fight off infections and ward off cancers,” says Randy Cron, M.D., Ph.D, at the University of Alabama at Birmingham, “But when they are out of control, they can make you very ill.”

While some research has found an elevated presence of cytokines in coronavirus patients, there isn’t enough data to say all rapidly-declining cases of COVID-19 are a result of a cytokine storm–the immune system gone rogue.

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COVID-19 Prevention: Avoid Touching Your Face

Posted on September 11, 2020 by admin

According to one infectious disease doctor, if you want to stay coronavirus-free there is one single thing you should avoid touching at all costs: YOUR FACE.

The Centers for Disease Control and Prevention (CDC) states that COVID-19 is mainly spread from person-to-person, either between close contact or through respiratory droplets produced when an infected person coughs, sneezes or talks. If those respiratory droplets land on your hand and make contact with any open skin, or the mucous membranes of your mouth, nose or eyes, you may be at risk.

To help control the spread of the coronavirus disease (COVID-19), health officials say it’s very important for you to avoid touching your face. Touching your face (i.e., your mouth, nose, and eyes) allows the virus on your hands to reach moist, porous surface tissue, mucous membranes, where the coronavirus can enter your body and cause infection.

Not touching your facial mucous membranes, an area known as the “T-zone,” is perhaps the most important step you can take to prevent an infection, said William Sawyer, a family doctor in Sharonville, Ohio, and founder of Henry the Hand, a nonprofit organization that promotes hand hygiene.

“It’s the one behavior that would be better than any vaccine ever created,” Sawyer said. “Just stop this simple behavior. Stop picking, licking, biting, rubbing — it’s the most effective way to prevent a pandemic.”

On average, people touch their faces up to 23 times per hour, and once you’ve been told not to touch your face, it’s suddenly all you want to do.

Sometimes, it’s impossible to avoid touching your face. And since the virus can also live on surfaces for several days. if you touch a table that someone with the virus sneezed on earlier, then rub your eye, you could give yourself the virus. That’s why experts stress hand-washing as a key infection control measure. Wash before and after any hand-face contact, using soap and water for at least 20 seconds. If soap and water are not readily available, use a hand sanitizer that contains at least 60% alcohol.

https://youtu.be/d914EnpU4Fo

Washing your hands, along with stopping as many other instances of face-touching as you can, is one of your best defenses in helping you avoid getting infected by the coronavirus.

If you touch your face unconsciously throughout the day, think of physically touching something else without upping your risk of bacteria exposure like your elbow or leg.

It’s not enough to simply instruct people to stop touching their face, said Elliot Berkman, a psychology professor at the University of Oregon who studies habits and behaviors; people must be able to “outsmart their habit” or form a different one. One way to do that quickly is to change something in your environment, Berkman said. Wear something on your hands or face that can serve as a cue, an interruption to an automatic action.

References:

Mental Health Impact of COVID-19 Pandemic

Posted on September 6, 2020 by admin

“Many experts believe there’s going to be a second curve, which is the mental health impact of COVID.” Alison Malmon, founder and executive director of the nonprofit organization Active Minds

The pandemic has stressed the mental health and well-being of millions of Americans

During this unprecedented time of uncertainty and fear, it is likely that mental health issues and substance use disorders among Americans will be exacerbated. Since epidemics in the past have been shown to induce general stress and anxiety across a population and may lead to new mental health and substance use issues, according to The Pan American Health Organization (PAHO).

Experts warn of an upcoming wave of mental disorders because of coronavirus. In the past, unprecedented times like a pandemic are almost always accompanied by increases in depression, posttraumatic stress disorder (PTSD), substance use disorder, a broad range of other mental and behavioral disorders, domestic violence, and child abuse, according to a recent opinion piece published in the Journal of the American Medical Association, Sandro Galea, MD, MPH, DrPH, a professor at the Boston University School of Public Health.

“If the country continues to ignore the collateral damage — specifically our nation’s mental health — we will not come out of this stronger.” Benjamin F. Miller, PsyD, chief strategy officer at Well Being Trust.

Preliminary data shows the pandemic has already negatively affected people’s mental health and well-being, particularly college students, according to Catherine Grus, the American Psychological Association’s chief education officer. More than one in three adults in the U.S. have reported symptoms of anxiety or depressive disorder during the COVID-19 pandemic. The negative implications on mental health and well-being of social distancing practices and job loss related to the economic recession on mental health is significant and growing

According to a recent Kaiser Family Foundation poll, more than half of Americans — 56% –reported that worry or stress related to the outbreak has led to at least one negative mental health effect.

Those negative mental health and well-being effects include trouble with eating or sleeping, drinking alcohol more, frequent headaches or stomachaches, shorter tempers, and other health problems. Among frontline health care workers and their families, 64% reported worsened mental health, as did 65% of those who had lost income.

Another recent report, released Friday from the Well Being Trust, said the pandemic could lead to 75,000 additional “deaths of despair” from drug and alcohol misuse and suicide due to unemployment, social isolation, and fears about the virus.

Disproportionate impact on African Americans and people of color

Additionally, it’s important to address the fact that the pandemic and the economic fallout has disproportionately affected Black Americans and people of color who have experienced higher mortality rates due to the coronavirus, as well as higher rates of unemployment.

Patrice Harris, MD, immediate past president of the American Medical Association, says COVID-19 worsened the mental and physical health problems that African Americans were already having.

“Pre-COVID-19, in the last 8 to 10 years, we have seen an increase in the number of suicide attempts in our African American youth, increased reports of stress and anxiety in African Americans in general and, unfortunately, we have also seen an increase in a [lack of] access to mental health care,” she says. “That is the foundation from which we have entered … [the] COVID-19 pandemic.”

Since the pandemic came to the United States, Harris says, much of the country has shown signs of more anxiety, stress, and worry. “If you add that to the foundation that we have pre-existing conditions around health and equity, then it just adds to the level of stress, anxiety, and trauma felt by the [African American] community.”

Access to needed health care services was a concern prior to the pandemic

It is imperative that our society focus efforts to educate Americans, especially students and people of color, on issues such as stress, depression and anxiety, and provide ways to cope with these maladies. Many Americans will likely require mental health and substance use services. Consequently, the pandemic spotlights both existing and new barriers to accessing mental health and substance use disorder services.

Among households that report skipping or delaying health care during the pandemic, 4% state that as a result, their or a family member’s mental health condition worsened. For people with insurance coverage, an increasingly common barrier to accessing mental health care is a lack of in-network options for mental health and substance use care.

Limited access to mental health care and substance use treatment is in part due to a current shortage of mental health professionals, which will likely be exacerbated by the COVID-19 pandemic.

“People look at the pandemic and they tend to be drawn to the negative. If we can help shift people to look at the positive, it really helps because we know that neurons that fire together wire together.” Heather Aston, Program Manager, San Diego Access and Crisis Line

It’s helpful to learn about “distress tolerance” skills, which involve accepting that some problems are beyond one’s control. Instead of becoming mired in feelings of unfairness and anger, people can learn healthier ways of thinking and coping when they can’t escape painful situations like a pandemic and economic recession.

Even with the looming epidemic of mental health issues, experts say that people are resilient and can strive to protect their emotional well-being. People can develop their own psychological tools. Experts offer:

Try to to eat healthy, exercise daily and sleep well.
Try to stay socially connected with friends and families, even if you can’t see others in person.
Limit negative news and social media.

How Americans are coping during COVID-19

References:

Myocarditis, Inflammation of the Heart Muscle

Posted on September 4, 2020 by admin

Penn State doctor says 30-35% of Big Ten athletes testing positive for COVID-19 had myocarditis symptoms.

Cardiac MRI scans revealed that roughly a third of all athletes who have tested positive for the coronavirus appear to have myocarditis, an inflammation of the heart muscle, said Penn State’s director of athletic medicine.

Myocarditis is an inflammation of the heart muscle that can lead to arrhythmia, cardiac arrest and death, especially in a person who doesn’t know they have it and performs rigorous exercise. The risk of myocarditis was a prime reason behind the Big Ten Conference’s decision to postpone the upcoming football season.

According to the Mayo Clinic, “In many cases, myocarditis improves on its own or with treatment, leading to a complete recovery.”

Even in mild cases of myocarditis, however, the clinic suggests that “persons should avoid competitive sports for at least three to six months.”

The cause of COVID-19 myocarditis is unclear. Some researchers speculate that the coronavirus may sometimes directly infect the heart.

Another possible culprit is the immune system’s response against the virus. When it fires out of control — a severe inflammatory reaction known as a cytokine storm — it can damage organs throughout the body, including the heart.

References:

COVID-19 Frequently Asked Questions | New York Times

Posted on September 3, 2020 by admin

Updated September 1, 2020

Why is it safer to spend time together outside?

Pandemic life is safer outdoors. Outdoor gatherings lower risk because wind disperses viral droplets, and sunlight can kill some of the virus. Open spaces prevent the virus from building up in concentrated amounts and being inhaled, which can happen when infected people exhale in a confined space for long stretches of time, said Dr. Julian W. Tang, a virologist at the University of Leicester. Thus, while the risk of outdoor transmission is low, it can happen.

“The virus load is important,” said Eugene Chudnovsky, a physicist at Lehman College and the City University of New York’s Graduate Center. “A single virus will not make anyone sick; it will be immediately destroyed by the immune system. The belief is that one needs a few hundred to a few thousand of SARS-CoV-2 viruses to overwhelm the immune response.”

What are the symptoms of coronavirus?

In the beginning, the coronavirus seemed like it was primarily a respiratory illness — many patients had fever and chills, were weak and tired, and coughed a lot, though some people don’t show many symptoms at all. Those who seemed sickest had pneumonia or acute respiratory distress syndrome and received supplemental oxygen. By now, doctors have identified many more symptoms and syndromes. In April, the C.D.C. added to the list of early signs sore throat, fever, chills and muscle aches. Gastrointestinal upset, such as diarrhea and nausea, has also been observed. Another telltale sign of infection may be a sudden, profound diminution of one’s sense of smell and taste. Teenagers and young adults in some cases have developed painful red and purple lesions on their fingers and toes — nicknamed “Covid toe” — but few other serious symptoms.

Why does standing six feet away from others help?

The coronavirus spreads primarily through droplets from your mouth and nose, especially when you cough or sneeze. The C.D.C., one of the organizations using that measure, bases its recommendation of six feet on the idea that most large droplets that people expel when they cough or sneeze will fall to the ground within six feet. But six feet has never been a magic number that guarantees complete protection. Sneezes, for instance, can launch droplets a lot farther than six feet, according to a recent study. It’s a rule of thumb: You should be safest standing six feet apart outside, especially when it’s windy. But keep a mask on at all times, even when you think you’re far enough apart.

COVID-19 risk factors for severe disease

Based on currently available information and clinical expertise, older adults and people with underlying medical conditions are at higher risk for severe illness from COVID-19. According to the CDC, “…6% of the deaths, COVID-19 was the only cause mentioned.” Essentially, 94 percent of Americans who have died from coronavirus from the week ending February 1, 2020 to the week ending August 22, 2020 had, on average, almost three comorbidities that played a role in their death.
According to CDC’s report, the leading comorbidities among COVID-19 deaths were respiratory diseases, circulatory diseases, sepsis, malignant neoplasms, diabetes, obesity and Alzheimer’s disease, respectively.
“Anecdotally, there are several stories of cases in which people with COVID-19 had deadly heart attacks, yet these cases were coded as COVID-19 deaths. In one extreme case, a Florida man who died in a motorcycle crash happened to also have COVID-19 at the time, yet was coded as having died from COVID-19, not because of the motorcycle accident.” Many clinicians are putting COVID-19 on death certificates when it might not be entirely accurate because they died infected with coronavirus and not because of coronavirus.

Sources:

Sorrento Therapeutic’s COVID-19 Test

Posted on September 2, 2020 by admin

Sorrento’s COVID-19 test appears to be superior to competing diagnostics, and it just made a good acquisition, while its overall strategy is sound.

Sorrento has produced a coronavirus test which is expected to be approved and then become widely used in the U.S. and potentially around the world. The company requested emergency use authorization (EUA) from the Food and Drug Administration for its COVI-TRACK diagnostic test, which detects novel coronavirus antibodies. It also plans to file for an EUA for COVI-TRACE, a rapid salivary diagnostic test licensed from Columbia University.

Sorrento has been even more active in developing potential treatments for COVID-19. The biotech filed for FDA approval earlier this month to begin a phase 1 study of antibody therapy STI-1499 (COVI-GUARD) in treating hospitalized COVID-19 patients. It hopes to quickly advance the candidate through clinical testing and perhaps even receive an EUA for STI-1499 as soon as the end of 2020.

a number of test tubes and capsules are pictured under a cool blue light

Source: Shutterstock

Sorrento’s coronavirus test yields results in just 30 minutes, does not require lab equipment and doesn’t have to be sent to labs. As a result, it, unlike other tests, could be used by hospitals, stadiums, hotels, office buildings and other organizations to allow people to safely enter their facilities on the same day that the test is taken.

References:

Dexamethasone – first drug shown to reduce Covid-19 deaths

Posted on August 30, 2020 by admin

The most severe symptoms of COVID-19 are the result of the an infected person’s immune system’s overreaction to the virus. Dexamethasone is an anti-inflammatory drug that can rein in a person’s immune system attack.

Dexamethasone is a corticosteroid that prevents the release of substances in the body that cause inflammation. It is used to treat many different inflammatory conditions such as allergic disorders and skin conditions.

Dexamethasone is also used to treat ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders. It may also be used for purposes not listed in this medication guide.

This drug is relatively inexpensive and widely available steroid that blunts many types of immune responses. Doctors have long used it to treat allergies, asthma and inflammation.

In June, it became the first drug shown to reduce Covid-19 deaths. That study of more than 6,000 people, which in July was published in the New England Journal of Medicine, found that dexamethasone reduced deaths by one-third in patients on ventilators, and by one-fifth in patients on oxygen. It may be less likely to help — and may even harm — patients who are at an earlier stage of Covid-19 infections, however.

In its Covid-19 treatment guidelines, the National Institutes of Health recommends only using dexamethasone in patients with COVID-19 who are on a ventilator or are receiving supplemental oxygen.

Steroid medication affects your immune system. You may get infections more easily. Steroids can also worsen or reactivate an infection you’ve already had. Tell your doctor about any illness or infection you have had within the past several weeks.

References:

U.S. FDA Approves COVID-19 Plasma Treatment for Emergency Use Authorization

Posted on August 24, 2020 by admin

Eradicating the coronavirus, whether it’s through an effective therapeutic treatment or vaccine, is the key to unlocking the economy.

The U.S. Food and Drug Administration’s granted emergency use authorization of antibody-rich plasma from recovered patients which may lessen the severity of the disease, but experts suggest further research is needed.

Convalescent plasma therapy is an experimental treatment that some physicians are using for people with severe coronavirus disease 2019 (COVID-19). The plasma therapy has shown some promise in battling severe illness. People who’ve recovered from COVID-19 have antibodies — proteins the body uses to fight off infections — to the disease in their blood. The blood from people who’ve recovered is called convalescent plasma.

Researchers hope that convalescent plasma can be given to people with severe COVID-19 to boost their ability to fight the virus. It also might help keep people who are moderately ill from becoming more ill and experiencing COVID-19 complications, according to the Mayo Clinic.

Alex Azar, the U.S. health and human services secretary, said during a White House press briefing on Sunday that the treatment has been delivered to more than 70,000 American patients so far. The treatment, according to the FDA’s evaluation, “may be effective in lessening the severity or shortening the length of COVID-19 illness in some hospitalized patients.”

Source: The New York Times Coronavirus Vaccine Tracker

Over 400 vaccines and therapietic treatments are under study as researchers rush to produce effective medicines for the disease. And, 32 of the vaccines are in human trials. The FDA says that for any vaccine to be approved, it will need to prevent infection or decrease its severity in at least 50% of the people vaccinated. The goal is to inoculate enough people with a vaccine that immunity spreads through a community, even if not everyone gets the vaccine. It’s called “herd immunity”, according to WebMD.

For this coronavirus, some experts say about 60% to 70% of the population would need to develop antibodies, whether from a vaccine or getting and recovering from COVID-19, to create herd immunity.

Currently, the most effective ways to protect yourself and others from being infected by the virus are to:

Clean your hands frequently and thoroughly
Avoid touching your eyes, mouth, and nose
Cover your cough with the bend of elbow or tissue
Stay home and isolate yourself if you feel ill or ‘under-the-weather’
Maintain social physical distance of at least 6 feet from others

Wearing a mask or face covering is no substitute for these additional effective measures.

References:

SalivaDirect – FDA authorizes new saliva based COVID-19 test

Posted on August 18, 2020 by admin

Food and Drug Administration (FDA) commissioner Stephen Hahn called the development of a new and inexpensive saliva test for COVID-19 ”ground-breaking.” The new COVID test, which uses saliva instead of nasal swabs, is also a much less intrusive test than the nasal test.

The Food and Drug Administration on Saturday authorized emergency use of a new and inexpensive saliva test for Covid-19 that could greatly expand testing capacity. The new test is called SalivaDirect and was developed by researchers at the Yale School of Public Health.

The test method allows saliva samples to be collected in any sterile container. And, it is a much less invasive process than the nasal swabs currently used to test for the virus that causes Covid-19, but one that has so far yielded highly sensitive and similar results. This test is being further validated as a test for asymptomatic individuals through a program that tests players and staff from the National Basketball Association (NBA).

SalivaDirect is simpler, less expensive, and less invasive than the traditional method for nasal swab testing. Results so far have found that SalivaDirect is highly sensitive and yields similar outcomes as nasal swabbing.

“We simplified the test so that it only costs a couple of dollars for reagents, and we expect that labs will only charge about $10 per sample,” said Nathan Grubaugh, a Yale assistant professor of epidemiology. “If cheap alternatives like SalivaDirect can be implemented across the country, we may finally get a handle on this pandemic, even before a vaccine.”

With the FDA’s emergency use authorization, the testing method is immediately available to other diagnostic laboratories that want to start using the new test, which can be scaled up quickly for use across the nation. A key component of SalivaDirect is that the method has been validated with reagents and instruments from multiple vendors.

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Recommendation to wear eye protection against coronavirus

Posted on August 14, 2020 by admin

“If you have goggles or an eye shield, you should use it. It’s not universally recommended, but if you really want to be complete, you should probably use it if you can.” Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases

Updated: August 13, 2020 at 4:59 p.m. ET.

Based on what doctors know about how Covid-19 spreads, it’s possible to get infected through your eyes, but not common. However, it makes sense to use eye protection and a mask anywhere you can’t effectively maintain social distance from others for an extended period such as on board a plane or in a classroom.

Wearing eye protection in public to fend off COVID-19, according to Dr. Fauci, “…is not universally recommended, but if you really want to be complete, you should probably use it if you can.” But one reason that this hasn’t been pushed for the general public yet, he suggested, is because, “it’s so easy for people to just make a cloth mask.”

GETTY IMAGES

Glasses or sunglasses can provide some protection, but due to the openings on the top, bottom and sides, aerosols could still get in.

Face shields and protective goggles are advised by medical experts. Protective eye goggles should “fit snugly around the corners of the eye and across the brow. Face shields work because they protect the crown and chin from exposure, as well as the eyes. But, you still must wear a mask when wearing a face shield in order to cover your nose and mouth.

“If you have goggles or an eye shield, you should use it.” — Dr. Anthony Fauci

Fauci explained that the novel coronavirus that causes COVID-19 infects mucosal surfaces — or parts of the body including the eyes, nose and mouth that secrete mucus to stop pathogens and dirt from getting into your body. So “perfect protection” of your mucosal surfaces would include covering every one of them up, he said.

“Theoretically you should protect all of the mucosal surfaces, so if you have goggles or an eye shield, you should use it,” he said.

Centers for Disease Control and Prevention suggests protective eyewear for health care professionals, noting that “use of eye protection is recommended in areas with moderate to substantial community transmission.” As a result, doctors and nurses do wear goggles or face shields in areas where they are coming into close contact with COVID-19 patients.

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Category Archives: COVID-19

COVID-19 Lung and Heart Damage

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COVID-19 Prevention: Avoid Touching Your Face

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Mental Health Impact of COVID-19 Pandemic

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Myocarditis, Inflammation of the Heart Muscle

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COVID-19 Frequently Asked Questions | New York Times

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Sorrento Therapeutic’s COVID-19 Test

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Dexamethasone – first drug shown to reduce Covid-19 deaths

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