Tag Archives: Healthy Aging

Lifestyle Changes to Diet, Sleep, and Exercise—Paired with interventions Like Relaxation Exercises Could Reverse the Aging Process

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A group of mature women lowered their biological age by an average of 5 years in just 8 weeks by lifestyle change consisting of exercise, healthy diet and adequate sleep. 

In the United States, dix in ten adults have at least one chronic disease and four in ten adults have two or more [1]. These diseases are a major cause of morbidity and mortality and they put a significant burden on the U.S. healthcare system as well as the society at large [2].

Aging has been identified as a common driver of chronic diseases and an important target for extending Americans’ healthspan [3]. Life expectancy for Americans has increased dramatically, although not all of the years gained are healthy. It has been estimated that if we improve Americans’ collective healthspan by just one year the calculated savings are worth $38 trillion dollars, and if by 10 years those savings jump to $367 trillion dollars [4].

Biological age clocks, based on DNA methylation marks, have become important surrogate markers to assess the effectiveness of interventions at reducing biological age, with the expectation that biological age reductions will compress morbidity and extend mortality [5, 6].

Lifestyle changes to diet, sleep, and exercise—paired with interventions like relaxation exercises and supplements—could reverse the aging process, according to new research.

Six women between the ages of 46 and 65 underwent an eight-week program that included alterations to diet, sleep, and exercise. They were also given relaxation guidance, probiotic and phytonutrient supplements, and nutritional coaching.

Blood tests showed a reduction in biological age of up to 11 years in five of the six women, with the average participant experiencing a 4.6-year decrease, according to the study, published in March in the journal Aging.

References:

  1. About chronic disease. Center for Disease Control. 2022. https://www.cdc.gov/chronicdisease/about/index.htm.
  2. Woolf SH, Schoomaker H. Life Expectancy and Mortality Rates in the United States, 1959-2017. JAMA. 2019; 322:1996–2016. https://doi.org/10.1001/jama.2019.16932[PubMed]
  3. Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, et al. Geroscience: linking aging to chronic disease. Cell. 2014; 159:709–13. https://doi.org/10.1016/j.cell.2014.10.039[PubMed]
  4. Scott AJ, Ellison M, Sinclair DA. The economic value of targeting aging. Nat Aging. 2021; 1:616–23. https://doi.org/10.1038/s43587-021-00080-0
  5. Bergsma T, Rogaeva E. DNA Methylation Clocks and Their Predictive Capacity for Aging Phenotypes and Healthspan. Neurosci Insights. 2020; 15:2633105520942221. https://doi.org/10.1177/2633105520942221[PubMed]
  6. Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, Harrington HL, Houts R, Kothari M, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. Elife. 2022; 11:e73420. https://doi.org/10.7554/eLife.73420 [PubMed]
  7. https://fortune.com/well/2023/05/17/how-to-lower-biological-age-lifestyle-changes-diet-exercise-relaxation-probiotics/
  8. https://www.aging-us.com/article/204602/text

Autophagy

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Autophagy is your body’s rejuvenation process that can be turned on by fasting.

Autophagy is our body’s natural recycling process, a system our bodies have used for centuries to survive. It is our body’s way of renewing itself. It involves the breakdown of old, damaged cells and renews them into healthier versions of themselves.

Over time, our cells grow old and become more susceptible to damage, which leads to oxidative stress in the body. This occurs when the body is exposed to harmful substances in the environment called free radicals, which can increase the risk of disease and accelerate aging.

Autophagy’s sole purpose in life is to reverse this negative process as much as possible. It is your friend, and is a protective mechanism to preserve the health of your cells and your entire body.

During autophagy, cells identified as being damaged are broken down, destroyed, and parts of them are reused to generate healthy, more high-functioning cells.

This process needs to occur frequently and long enough to achieve its intended benefits. Fortunately, there are ways to induce autophagy more regularly to support healthy aging and longevity.[1] One of the best ways is through fasting.

Autophagy Fasting Benefits

There are multiple autophagy benefits to health, and fasting is one way to help you achieve these benefits more often.[2] This is the case with both intermittent fasting and prolonged fasting methods.

Denying your cells of nutrients when fasting gives your body (and liver) a break from digestion and allows it to focus on cell renewal.

It then begins to locate the damaged cells that need to go, recreating them to become stronger.

Here are a few possible autophagy benefits associated with fasting:[4]

  • Decreases oxidative stress that leads to early aging.
  • Destroys damaged cells that can cause disease.
  • Bolsters the removal of toxins from the body.
  • Improves hormonal balance.
  • Decreases inflammation.
  • Boosts skin health by increasing collagen production.
  • Supports proper nerve communication and function, helping your body work more efficiently.
  • Promotes the conversion of your food and nutrients into needed energy.

When it comes to your own autophagy fasting timeline and method, it’s important to know yourself and weigh out the pros and cons of starting an autophagy diet plan like fasting.

How to Induce Autophagy By Fasting

Here are a few tips and best practices if you want to start fasting to stimulate autophagy.

Fast for at least 24 hours – While the exact fasting schedule to stimulate autophagy is not yet set in stone, your body needs some time to prepare for autophagy. While some experts say it’s possible to induce autophagy after fasting for 14–18 hours, most research points to at least 24 hours to begin to see a notifiable autophagy effect. For this reason, at least a 24-hour fast with is generally recommended to stimulate autophagy.[5]

Consider extended fasting – It’s possible that more extended fasts of at least 24–48 hours may lead to even bigger autophagic activity. However, this is not easy or necessarily safe for many people to follow.[6] Extended fasting can be especially dangerous for those who take insulin or other medications to manage blood sugar, as this can result in hypoglycemia (low blood sugar).

Add certain foods to speed up the process – There are a few foods you can try to help support the autophagy process during your eating windows. This includes coffee, green tea, turmeric, and polyphenols called ellagitannins and ellagic acid that promote health.[7] These polyphenols break down into Urolithin A

There are other effective (and safe!) ways to induce autophagy that don’t involve drastically changing your diet or eating schedule.

Calorie Restriction

A continuous calorie restriction can provide the same autophagy fasting benefits by “starving” your cells of calories on a more regular basis. You don’t need to go super low on calories to achieve autophagy – just reducing by 10-40% of your maintenance calorie needs can be effective.[8]

To achieve this safely and effectively through this method, it’s best to work with a registered dietitian for guidance.

Exercise

If you need a little extra push to exercise more, let the healthy-aging benefits of autophagy get you going on those unmotivated days. Physical activity has been shown to induce autophagy in muscles, especially after higher intensity exercise like interval training or running.[9]

However, even more prolonged, moderate-intensity exercise like walking produces these same autophagy benefits – you may just have to do it for longer.

Autophagy is your body’s way of self-preserving to delay the aging process, optimize health, and protect you from disease. You hold the tools to induce it more often through your daily habits like fasting, calorie restriction, and exercise.

References:

  1. Nakamura S, Yoshimori T. Autophagy and Longevity. Mol Cells. 2018 Jan 31;41(1):65-72. doi: 10.14348/molcells.2018.2333. Epub 2018 Jan 23. PMID: 29370695; PMCID: PMC5792715.
  2. https://www.timelinenutrition.com/blog/autophagy-and-fasting-unleash-the-power-for-optimal-health

13 Habits Linked to a Long Life

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13 Habits Linked to a Long Life (Backed by Science) from Healthline.com

Eating a nutritious diet and exercising regularly may increase your life expectancy. Other factors, like overeating and drinking more than a moderate level of alcohol, may reduce your risk of certain diseases.

Magnesium

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Magnesium helps your body function properly, especially as it pertains to your muscular system, bones, and nervous system.

Magnesium matters.

  • 7 out of 10 Americans are below the Dietary Reference Intake for Magnesium, according to a USDA Agricultural Research Report
  • Sufficient magnesium intake is important in helping to maintain the function of the heart, muscles, and nervous system, support learning and memory performance in aging adults,  absorb and utilize potassium and calcium properly
  • Magnesium is also critical for athletes’ endurance in order to help maintain electrolyte and energy levels.
  • Adults with certain health concerns or who are taking medication may need magnesium supplementation. Magnesium can be found in foods such as green and leafy vegetables, halibut, nuts, such as almonds, and sunflower seeds.

Magnesium is a mineral that’s essential for making proteins and promotes normal nerve cell communication, muscle contraction, and a normal heart rhythm.

It’s estimated that up to 70 percent to 90 percent of the population are magnesium deficient, according to some findings.

This means that the majority of people living in industrialized nations, even many who think they eat a mostly “balanced diet,” are missing out on the many benefits of magnesium. These include its ability to help manage pain, decrease digestive issues and support quality sleep.

Magnesium is the fourth most abundant mineral in the body and assists with more than 300 bodily reactions that occur constantly. About 50% of magnesium is found in bones, and the other half is divided among cells that make up your tissues and organs.*

A mere 1% of the magnesium in your body circulates in the bloodstream, but that small fraction doesn’t accurately convey magnesium’s importance there, as the body makes maintaining blood magnesium levels a high priority.*

Magnesium is important because it assists in the movement of calcium and potassium across cell membranes, magnesium plays a mighty role in promoting normal nerve cell communication, muscle contraction, and a normal heart rhythm. Magnesium also helps to maintain the strength of cell membranes and bones. Diets that provide recommended levels of magnesium are considered beneficial for bone health.*

Magnesium is an essential mineral that’s very important for many aspects of health, since it’s involved in hundreds of bodily functions, including:

  • Blood pressure regulation
  • Protein synthesis
  • Energy production
  • Blood sugar control
  • Digestive processes like moving stools through the intestine
  • Regulation of heartbeat rhythms
  • Neurotransmitter functions, including those involved in sleep and mood stabilization
  • Balance of nitric oxide in the body
  • Growth and development in babies and children
  • Functions of nerves, muscles and tissue
  • Production of stomach acid

Source: https://www.centrum.com/learn/vitamins-minerals/magnesium/

Positive Beliefs About Aging are Good for Memory Recovery

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From WebMD.com

Older people with mild cognitive impairment (MCI) are more likely to recover their function if they feel good about aging, compared to those who have negative emotions about it, a new study from the Yale School of Public Health says.

MCI is a common form of memory loss. Positive beliefs about aging give older people a 30% better chance of recovering normal thinking.

“Researchers also found that these positive beliefs also enabled participants to recover their cognition up to two years earlier than those with negative age beliefs,” Neuroscience News reported. “This cognitive recovery advantage was found regardless of baseline MCI severity.”

More than 1,700 people over age 65 participated in the study, which was published in JAMA Network Open.

“In previous experimental studies with older persons, positive age beliefs reduced stress caused by cognitive challenges, increased self-confidence about cognition, and improved cognitive performance,” study authors wrote. “We therefore hypothesized that older persons with positive age beliefs would be more likely to recover from MCI and would do so sooner compared with individuals with negative age beliefs.”

“Older persons in the positive age-belief group who started the study with normal cognition were less likely to develop MCI over the next 12 years than those in the negative age-belief group, regardless of their baseline age and physical health,” Neuroscience News reported.

“Considering that positive age beliefs can be strengthened, our findings suggest that age-belief interventions at individual and societal levels could increase the number of people who experience cognitive recovery,” the study said.

References:

  1. Jay Croft, “Positive Beliefs About Aging are Good for Memory Recovery”, WebMD.com, April 13, 2023. https://www.webmd.com/balance/news/20230413/positive-beliefs-about-aging-are-good-for-memory-recovery

Exercise as Medicine: Just Get Moving!

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You can come up with a million reasons for not being physically active.

Roughly 3.2 million people die each year because of physical inactivity, according to WebMD. Regular exercise — aerobics, resistance, stretching and balance — especially among older adults, is critical to good health.

Healthspan is more important than lifespan. On average, people live up to 20% of our lives unhealthy. ~ Institute for Public Health

But it’s important to know that stillness or lack of exercise is bad for your longevity and healthspan.  “Healthspan” can be defined as the period of one’s life that one is healthy, according to the Institute for Public Health. However, being “healthy” means being free from serious disease. A disease is considered to be serious if it is a leading cause of death.

Caring about extending the well period of one’s life should be intuitive – if one is past their healthspan, it means they are chronically sick, often with a degenerating condition. Therefore, most people would agree that staying within their healthspan is desirable.

To extend a person’s healthspan, first healthcare professionals must be able to measure it.  Once they can measure it, then they can improve it.

Unlike the average lifespan, which is now 79.3 years in the US, healthcare professionals don’t have a statistic to mark the end of the average healthspan. To address this, the World Health Organization (WHO) has developed an indicator, HALE – healthy life expectancy.

To improve healthspan, treatments are required, but treatments don’t necessarily mean drugs. First, there are many commonalities around lifestyle that could delay the onset of most, if not all, of the serious diseases. It might seem like common sense, but maintaining a healthy plant-based diet with regular exercise and without smoking and drinking alcohol and nurturing strong social relationships are the surest ways to promote one’s healthspan and limit the onset of most diseases.

Food, Exercise and Social Connections as Medicine to improve Healthspan.

Resistance:

  1. https://www.webmd.com/healthy-aging/ss/slideshow-truth-about-exercise-aging
  2. https://publichealth.wustl.edu/heatlhspan-is-more-important-than-lifespan-so-why-dont-more-people-know-about-it/
  3. http://apps.who.int/gho/data/view.main.HALEXREGv

Healthy Aging: Nicotinamide Riboside

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Blog Post at a Glance

  • The trace nutrient nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+) and a form of vitamin B3, may help slow brain aging
  • NR may help to boost levels of NAD+, which typically declines in the brain with age, leading to metabolic and cellular dysfunction
  • The NAD+ precursor niacinamide is also beneficial, but it’s not widely promoted because it costs much less than other NAD+ precursors, including NR
  • Since NAD+ declines with age, boosting it has been described as a fountain of youth for extended lifespan and increased resilience to disease

Nicotinamide Riboside (B3) is often celebrated as a “fountain of youth” and has been linked to many health benefits, including better endurance, improved cardiovascular health, cognitive enhancement, and anti-aging support.

Nicotinamide riboside is naturally produced in our bodies. It’s a chemical compound which acts as a precursor to vitamin B3.

For a long time, nobody really knew about nicotinamide riboside. Its mechanisms were not well-understood and, at first glance, it didn’t look like it profoundly affected the body in any way.

Over the past decade, a number of studies have been performed on nicotinamide riboside, radically changing the way scientists think and feel about this chemical compound.

Nicotinamide riboside has been linked to a number of surprising and powerful benefits. Early research on the chemical has been noteworthy.

Established scientist from Harvard and Cornell University have had much to say about this breakthrough anti-aging fighter that is making 55 year old individuals feel like they are 35 in the gym again.

That research, performed by Dr. David Sinclair of Harvard Medical School, showed that each mouse’s cell age decreased from 2 years to 6 months after being given molecules of Nicotinamide Riboside. In other words, mice that were 2 years old had the cells of 6 month old mice after being administered Nicotinamide Riboside.

So not only does Nicotinamide Riboside reduce the effects of aging, it actually appears to turn back time and make the cells function like they did when they were younger.

One recent nicotinamide riboside study concluded that taking nicotinamide riboside as an oral supplement, “resulted in a remarkable induction of mitochondrial biogenesis and oxidative metabolism, with an increase in mitochondrial mass.”

Mitochondria is directly linked to aging. As our bodies age, our mitochondrial production – and functionality – declines. This leads to a wide range of degenerative diseases and ultimately makes us look and feel older.

By promoting mitochondrial biogenesis, nicotinamide riboside may be able to “kickstart” the body’s anti-aging processes in a way that no other chemical compound can. That means you look, feel, and think younger.

Nicotinamide Riboside (NR) acts as a highly effective NAD+ booster, but it also works as a vitamin B3 (niacin) supplement.

Nicotinamide adenine dinucleotide (NAD+) is a key coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base, and the other contains nicotinamide.

NAD+ is essential for life, one of the most versatile molecules in the body, and an important area of focus for aging research.

Since NAD+ declines with age, boosting it has been described as a fountain of youth for extended lifespan and increased resilience to disease.

In 2020, James Clement, author of “The Switch: Ignite Your Metabolism With Intermittent Fasting, Protein Cycling, and Keto,” said NAD+ may be depleted by 50% by the time you’re 60 (compared to in your 20s or 30s), and when you’re 70 you may only have 10% of the amount you did when you were younger.

“And then at 80, there’s almost none,” he said, adding that this will seriously impair your body’s ability to repair broken DNA. “You can see how this huge build-up of damaged DNA in every cell of your body is potentially one of the driving forces of these morbidities that you see with aging, heart disease, cancer [and] Alzheimer’s …“

Nicotinamide riboside is one of the most effective NAD+ precursors to support nucleus and mitochondrial health. That means it boosts cellular energy and reduces the effects of aging by enhancing cellular communication throughout the body and mind.

References:

  1. https://supplementpolice.com/niagen/
  2. https://supplementpolice.com/nicotinamide-riboside/
  3. https://drjosephmercola.com/could-this-vitamin-slow-brain-aging-and-ward-off-alzheimers/

Four Types Of Exercise Can Improve Your Health And Physical Ability

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Research has shown that it’s important for older Americans to get all four types of exercise or physical activity:

  • Endurance (aerobics),
  • Strength and Resistant,
  • Balance, and
  • Flexibility.

Each exercise or physical activity has different benefits for your health and well-being. Additionally, doing one or more kind of exercise can improve your ability to do the others, and variety helps reduce risk of injury and promote healthy aging over the long term.
Endurance exercises for older adults

Four Types of Exercise infographic. Click to open infographic webpage.

Endurance activities or aerobic exercises increase your breathing and heart rates. These activities help keep you healthy, improve your fitness, and help you perform the tasks you need to do every day. Endurance exercises improve the health of your heart, lungs, and circulatory system. They also can delay or prevent many diseases that are common in older adults such as diabetes, colon and breast cancers, heart disease, and others. Physical activities that build endurance include:

  • Brisk walking or jogging
  • Yard work (mowing, raking)
  • Dancing
  • Swimming
  • Biking
  • Climbing stairs or hills
  • Playing tennis or basketball

Increase your endurance or “staying power” to help keep up with your grandchildren during a trip to the park, dance to your favorite songs at a family wedding, and rake the yard and bag up leaves. Build up to at least 150 minutes of activity a week that makes you breathe hard. Try to be active throughout your day to reach this goal and avoid sitting for long periods of time.

Gauging your exercise intensity

When you’re being active, try talking: if you’re breathing hard but can still have a conversation easily, it’s moderate-intensity activity. If you can only say a few words before you have to take a breath, it’s vigorous-intensity activity.

References:

  1. https://www.nia.nih.gov/health/four-types-exercise-can-improve-your-health-and-physical-ability

Health: There are No Limits

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“Once you pass the age of fifty, exercise is no longer optional. You have to exercise or get old.” ~ Dr. Henry S. Lodge. M.S., Younger Next Year, pg. 113.

People tend not to exercise because they are tired at the end of the day, But, in reality, people are tired at the end of the day not because they get to much exercise of physical exertion, explains Dr. Henry S. Lodge. M.D., leading NY internist and Columbia Medical School Professor. Instead, people are tired at the end of the day because they do not get enough exercise and as a result, they are not fit.

People are mentally, emotionally and physically drained and exhausted from being sedentary, states Dr. Lodge. Study after steady demonstrates that productivity increases and an individual functions better each day when they are fit. In short, time spent exercising and getting fit is life enhancing and extending.

So, make daily exercise a habit or routine like taking a shower or brushing your teeth. In short, your body craves the body’s chemical reaction resulting from exercise and movement.  So it’s important for you to “Do Something Everyday”.

Start exercising at a level that matches your current level of fitness, Dr. Lodge urges. Start out a level that is hard enough to make you sweat like walking at a brisk pace for twenty to thirty minutes. But, before you get started, check with your medical doctor.

Getting and staying fit is wonderful if you’re healthy, but it’s essential and life saving if you’re not healthy. Your life will improve dramatically once you commit to the habit of regular exercise.

Your long term endurance exercise goal should be to do long and slow aerobic exercise for three hours or more at 60% to 65% of maximum heart rate for three hours without getting exhausted.  You should be able to do something like an all morning bike ride for three hours or more well into your sixties, seventies, eighties and nineties.  You should make a real commitment to do something like that at least once a month

If you can get to the level of three hours or more of endurance exercise and stay there, life will be good, says Chris Crowley, New York Times bestselling co-author of “Younger Next Year”. Crowley recommends that you:

  1. Exercise six days a week for at least 30 minutes for the rest of your life.
  2. Do serious aerobic exercise four days a week for the rest of your life.
  3. Do serious strength training, with weights or body weight, two days a week for the rest of your life.
  4. Eat healthy foods and drink plenty of water. Quit eating crappy food like refined sugar, refined carbs and processed foods.
  5. Maintain close relationships and social connections.
  6. Get adequate sleep and reduce stress.
  7. Have an attitude of gratitude.  Always be grateful.

“Open heart surgery is hugely popular these days, apparently because so many guys prefer it to learning about aerobic exercise and working out.” ~ Chris Crowley, Younger Next Year, pg. 116.

Crowley believes that it’s possible that Americans, as a society, “can be radically healthier, more energetic, more fit, more optimistic and effective by making modest, behavioral changes. Putting off 70% of today’s aging is a simple matter: Move a lot more!…quit eating crap!…connect with others!, he emphasizes.” The combination of sedentary lifestyle  and the crappy food we eat is wrecking Americans lives and ruining the economy. The nation spends “20% of our national income on health care”. Half of the amount spent on healthcare could be saved “because 50% of our bad health is simply the result of the ridiculous way we eat and live.”

Final thoughts…staying deeply connected with and caring about family and friends and others are essential for healthy aging and longevity. Staying in touch… caring… is hugely important.

References:

  1. Chris Crowley and Henry S. Lodge, M.D., Younger Next Year, Workman Publishing, 2nd Edition, New York, December 24, 2019.
  2. https://www.youngernextyear.com/bios/

“Younger Next Year: Live Strong, Fit, Sexy, and Smart―Until You’re 80 and Beyond” – According to authors Chris Crowley and Dr. Henry S. Lodge, M.D., men 50 or older can become functionally younger every year for the next five to ten years, and continue to live like fifty-year-olds until well into their eighties. To enjoy life and be stronger, healthier, and more alert. To stave off 70% of the normal decay associated with aging (weakness, sore joints, apathy), and to eliminate over 50% of all illness and potential injuries.

Anti-Aging and Keeping Mitochondria Healthy

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Nicotinamide riboside — also called niagen — is a form of vitamin B3 that might be able to reverse signs of aging and might keep your mitochondria, the powerhouses of the cell, healthy.

One of the hallmarks of aging is a process known as “mitochondrial dysfunction”, a term that refers to our cells’ general loss in power and efficiency over time. It may be one of the reasons we age at all. Mitochondrial dysfunction occurs when your mitochondria lose the ability to function normally. It can happen if the mitochondria present in your cells are not functioning as they should. And if the mitochondria are at the heart of why we age, it makes sense to look at every possible way of keeping them functioning for as long as possible.

That’s one of the reasons why some of the world’s leading scientists are turning to nicotinamide riboside. This unique form of vitamin B3 shows the potential to affect mitochondrial health and in turn, many of the age-related problems associated with it.

Understanding the mitochondria.

Inside almost every cell are these tiny, strangely shaped organelles called mitochondria— “the powerhouses of the cell.” These mini-organs are responsible for producing 90% of the energy we need in our bodies. The mitochondria are the reason why we exist as the complex animals we are today, rather than bacteria.

We didn’t always know just how vital the mitochondria were to our health. One key way of keeping mitochondria healthy is a molecule known as NAD+ (nicotinamide adenine dinucleotide). Our cells naturally produce NAD+, and we use it constantly throughout the day.

We also know our NAD+ supply declines as we age. Once researchers realized NAD+ could be the key to keeping our cells healthy, they scrambled for a way to make more of it.

The beginning of the vitamin B3s.

Researchers already knew of two vitamins that began the chemical process to increase NAD+: niacin and nicotinamide. These were discovered in the 1930s and used to treat pellagra, a potentially deadly vitamin B3 deficiency disease.

Niacin would also go on to be a treatment for high cholesterol in the 1950s. However, people found that ingesting niacin in high doses sometimes resulted in an annoying skin flush that was both irritating and unsightly.

Nicotinamide didn’t cause the skin flush and could in theory provide a lot of the same benefits, but it inhibited the activation of important cellular repair promoting proteins known as sirtuins. Neither nicotinamide nor niacin were as effective as researchers were hoping they’d be.

Although these two vitamins were NAD+ precursors, they weren’t ideal solutions. With niacin’s negative side effects, and the relative effectiveness of nicotinamide, researchers still didn’t have a good enough vitamin supplement for increasing NAD+ levels.

The discovery of nicotinamide riboside.

Another vitamin B3 known as nicotinamide riboside was discovered in the 1940s in yeast. But it wasn’t until the early 2000s that scientists began to see the potential of this third form of vitamin B3 to not only increase NAD+ but also improve human health in general. In 2004, a Dartmouth College research team discovered that nicotinamide riboside, like its vitamin B3 brothers, was also a precursor to NAD+.

The team, led by Charles Brenner, PhD, found that nicotinamide riboside could increase NAD+ in mice and that those mice experienced a plethora of health benefits as a result.

The mice showed everything from improved blood sugar levels and cholesterol levels to reduced nerve damage, and resistance to weight gain. Dr. Charles Brenner found these results so inspiring, he took the next step to see what nicotinamide riboside could mean for human health.

In 2014, Dr. Charles Brenner became the first human to consume nicotinamide riboside as a supplement. The results were just as promising. This relatively unknown form of vitamin B3 significantly increased his NAD+ levels safely, quickly, and without any negative side effects.

Conclusion

Nicotinamide riboside (NR), also called niagen, is an alternative form of vitamin B3. NR is promoted as an anti-aging supplement because it is converted by your body into nicotinamide adenine dinucleotide (NAD+), a coenzyme or helper molecule, which is critical to cellular repair and the repair of damaged DNA, and which acts as fuel for many key biological processes, such as:

  • Converting food into energy
  • Repairing damaged DNA
  • Fortifying cells’ defense systems
  • Setting your body’s internal clock or circadian rhythm

“NAD+ is gradually lost as we get older or develop chronic diseases. Loss of NAD+ is linked to obesity and other negative lifestyle habits like smoking,” Christopher Martens, assistant professor of kinesiology and applied physiology and director of the Delaware Center for Cognitive Aging Research said. “Because more NAD+ is needed to counteract those negative consequences, it’s more likely to be depleted in the face of negative lifestyle habits.”

References:

  1. https://www.truniagen.com/blog/our-ingredient/is-nicotinamide-riboside-really-an-anti-aging-supplement/
  2. https://www.truniagen.com/blog/science-101/mitochondria-the-powerhouse-of-the-cell/
  3. https://www.healthline.com/nutrition/nicotinamide-riboside
  4. https://neurosciencenews.com/nicotinamide-riboside-alzheimers-22550/