Immune Response from COVID-19 Vaccine

Experiencing an immune response was better than getting Covid-19

Many participants in Moderna and Pfizer’s coronavirus vaccine trials experienced an “immune response” such as high fever, body aches, bad headaches, daylong exhaustion and other symptoms after receiving the COVID-19 vaccine shots.

While the symptoms were uncomfortable for many, the participants said the symptoms went away after a day, sometimes sooner, and that “it was better than getting Covid-19”.

“We really need to make patients aware that this [COVID-19 vaccine] is not going to be a walk in the park,” Dr. Sandra Fryhofer of the American Medical Association said. “They are going to know they had a vaccine. They are probably not going to feel wonderful. But they’ve got to come back for that second dose.”

Both companies, Moderna and Pfizer, acknowledged that their vaccines could induce “immune response” — side effects — that are similar to symptoms associated with mild COVID-19, such as muscle pain, chills and headache.

It’s normal to feel under the weather or even somewhat ill—fatigued, achey, or experience a fever—after getting a vaccine shot. This results from the robust immune response as the body’s creating antibodies, actual protection against the coronavirus. It will happen to a percentage of the people who get the vaccine shot.

In other words, feeling like you’re in the early stages of getting the coronavirus is actually a sign that you’ll be protected from the actual virus. What you’re feeling is the body’s defense system gearing up.

Most vaccine shots mimic a virus entering your body. Immune cells, though, fire off chemical alarms as soon as they notice any virus-like particle. They activate the innate immune system, a generalized response that tries to make the body unlivable for any potential pathogen. That inflammatory reaction can cause a bit of a fever or a tiny swollen lump near the injection site.

The fatigue you might feel comes from gearing up a more specialized immune defense. Tiny, specialized cells called B-cells create antibodies, which are cellular fighter pilots specific to each virus. Making these antibodies requires expending a little extra energy at first, but the payoff is future protection: Once they’re present in your plasma, the antibodies can patrol for future viruses.

Additionally, it takes about two weeks for your body to whip its antibodies into shape; you could pick up a coronavirus in the window between getting your jab and when protection kicks in. That’s why it’s important to make sure you only get a coronavirus vaccine shot, or any vaccine, when you’re feeling healthy.

Not everyone will notice these symptoms after getting the vaccine shot. But if you do seem a bit off, the feeling shouldn’t stick around for more than a day or two, and shouldn’t require a visit to your healthcare provider.


References:

  1. https://www.cnbc.com/2020/11/23/covid-vaccine-cdc-should-warn-people-the-side-effects-from-shots-wont-be-walk-in-the-park-.html
  2. https://finance.yahoo.com/news/feeling-sick-getting-flu-shot-150519027.html